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Prokineticin
From Wikipedia, the free encyclopedia
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Prokineticin is a secreted protein that potently contracts gastrointestinal smooth muscle.[2]
Recently, prokineticins have been recognized in humans and other vertebrates.[3] They are thought to be involved in several important physiological processes like neurogenesis, tissue development, angiogenesis, and nociception.[3][4] Other important physiological roles the Bv8/Prokineticins (PKs) are involved in may include cancer, reproduction, and regulating physiological functions that influence circadian rhythms like hormone secretion, ingestive behaviors, and the sleep/wake cycle.[5]
Mutations in the PROK2 (also known as KAL4) gene have been implicated in hypogonadotropic hypogonadism and gynecomastia.[6]
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