Promestriene

Promestriene (INNTooltip International Nonproprietary Name) (brand names Colpotrofin, Colpotrophine, Delipoderm), also known as estradiol 3-propyl 17β-methyl diether, is a synthetic estrogen which is used topically in a 1% cream formulation for the treatment of vaginal atrophy in women.^{[1][2][3][4][5]} It is the 3-propyl and 17β-methyl diether of estradiol and does not appear to convert into estradiol in the body.^[1][6] Promestriene is minimally absorbed and appears to have negligible systemic estrogenic effect.^[1] The drug has been described as a tropic agent and antiseborrheic.^[2] It has not been found to be effective in the treatment of pattern hair loss or other conditions of cutaneous androgenization.^[7][8] Promestriene was first introduced in France in 1974 and has been marketed in 34 countries worldwide.^[1] It has been used in millions of women.^[1]

Promestriene

Clinical data
Trade names	Colpotrofin, Colpotrophine, Delipoderm
Other names	Estradiol 3-propyl 17β-methyl diether; 17β-Methoxy-3-propoxyestra-1,3,5(10)-triene
Routes of administration	Topical
Drug class	Estrogen; Estrogen ester
ATC code	G03CA09 (WHO)
Identifiers
IUPAC name (8R,9S,13S,14S)-17-methoxy-13-methyl-3-propoxy-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene
CAS Number	39219-28-8
PubChem CID	71717
ChemSpider	64767 Y
UNII	GXM4PER6WZ
CompTox Dashboard (EPA)	DTXSID2057730
ECHA InfoCard	100.049.401
Chemical and physical data
Formula	C22H32O2
Molar mass	328.496 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCCOc1ccc2c(c1)CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CCC4OC)C
InChI InChI=1S/C22H32O2/c1-4-13-24-16-6-8-17-15(14-16)5-7-19-18(17)11-12-22(2)20(19)9-10-21(22)23-3/h6,8,14,18-21H,4-5,7,9-13H2,1-3H3/t18-,19-,20+,21?,22+/m1/s1 N Key:IUWKNLFTJBHTSD-QIKJAYGVSA-N N
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See also

• List of estrogen esters § Ethers of steroidal estrogens