Propacetamol

Propacetamol is a prodrug form of paracetamol which is formed from esterification of paracetamol, and the carboxylic acid diethylglycine. This has the advantage of making it more water-soluble. It is used in post-operative care and is delivered by I.V.^[2] It is given if the patient is unable to take oral or rectally delivered paracetamol and nonsteroidal anti-inflammatory drugs (NSAIDs) are contraindicated. The onset of analgesia from propacetamol is more rapid than paracetamol given orally.^[3] 2 grams of propacetamol are equivalent to 1g of paracetamol.^[4]

Propacetamol

Clinical data
AHFS/Drugs.com	International Drug Names
Routes of administration	IV[1][2]
ATC code	N02BE05 (WHO)
Pharmacokinetic data
Elimination half-life	2.4 hours [1]
Excretion	Renal
Identifiers
IUPAC name 4-(acetamido)phenyl N,N-diethylglycinate
CAS Number	66532-85-2
PubChem CID	68865
ChemSpider	62097
UNII	5CHW4JMR82
CompTox Dashboard (EPA)	DTXSID3057800
ECHA InfoCard	100.060.336
Chemical and physical data
Formula	C14H20N2O3
Molar mass	264.325 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCN(CC)CC(=O)OC1=CC=C(C=C1)NC(=O)C
InChI InChI=1S/C14H20N2O3/c1-4-16(5-2)10-14(18)19-13-8-6-12(7-9-13)15-11(3)17/h6-9H,4-5,10H2,1-3H3,(H,15,17) Key:QTGAJCQTLIRCFL-UHFFFAOYSA-N
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See also

• Phenacetin