Propanidid

Propanidid is an ultra short-acting phenylacetate general anesthetic. It was originally introduced by Bayer in 1963^[2] but anaphylactic reactions caused it to be withdrawn shortly afterwards.

Propanidid

Clinical data
Trade names	Epontol
AHFS/Drugs.com	International Drug Names
ATC code	N01AX04 (WHO)
Legal status
Legal status	BR: Class C1 (Other controlled substances)[1]
Identifiers
IUPAC name Propyl {4-[2-(diethylamino)-2-oxoethoxy]-3-methoxyphenyl}acetate
CAS Number	1421-14-3 Y
PubChem CID	15004
DrugBank	DB13234 N
ChemSpider	14283 Y
UNII	AO82L471NS
KEGG	D05626 Y
ChEBI	CHEBI:135432
ChEMBL	ChEMBL2105345
CompTox Dashboard (EPA)	DTXSID7048825
ECHA InfoCard	100.014.384
Chemical and physical data
Formula	C18H27NO5
Molar mass	337.416 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C(OCCC)Cc1cc(OC)c(OCC(=O)N(CC)CC)cc1
InChI InChI=1S/C18H27NO5/c1-5-10-23-18(21)12-14-8-9-15(16(11-14)22-4)24-13-17(20)19(6-2)7-3/h8-9,11H,5-7,10,12-13H2,1-4H3 Y Key:KEJXLQUPYHWCNM-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Even though Cremophor EL has been shown to cause anaphylactic reactions in humans in several cases (both when given intravenously and orally), it is still debated whether propanidid itself may have contributed to the reactions.

It has been argued that the toxic effects or reactions to propanidid (and Althesin) were due to the drugs themselves.^[3] Several cases of negative reactions have been recorded for different drugs using Cremophor EL as solubilizer, suggesting that the negative reactions were mainly caused by Cremophor and not by the drug substances themselves.