Propylpyrazoletriol

Propylpyrazoletriol (PPT) is a synthetic, nonsteroidal agonist of ERα with 400-fold selectivity over ERβ^[1] that is used widely in scientific research to study the function of ERα.^[2][3][4] Though originally thought to be highly selective for ERα, PPT has subsequently been found to also act as an agonist of the GPER (GPR30).^[5]

Propylpyrazoletriol

Identifiers
IUPAC name 4-[2,3-bis(4-hydroxyphenyl)-4-propyl-1H-pyrazol-5-ylidene]cyclohexa-2,5-dien-1-one
CAS Number	263717-53-9
PubChem CID	6095481
ChemSpider	16142497
UNII	0T83Y6JZPF
CompTox Dashboard (EPA)	DTXSID9040392
Chemical and physical data
Formula	C24H22N2O3
Molar mass	386.451 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCCC1=C(N(NC1=C2C=CC(=O)C=C2)C3=CC=C(C=C3)O)C4=CC=C(C=C4)O
InChI InChI=1S/C24H22N2O3/c1-2-3-22-23(16-4-10-19(27)11-5-16)25-26(18-8-14-21(29)15-9-18)24(22)17-6-12-20(28)13-7-17/h4-15,25,28-29H,2-3H2,1H3 Key:UOSWGERPQQOSHS-UHFFFAOYSA-N

See also

• ERA-45
• ERA-63
• GTx-758
• Methylpiperidinopyrazole (MPP)