Solute carrier organic anion transporter family member 2A1

Solute carrier organic anion transporter family member 2A1, also known as the prostaglandin transporter (PGT), is a protein that in humans is encoded by the SLCO2A1 gene.^[5]

SLCO2A1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3MRR
Identifiers
Aliases	SLCO2A1, MATR1, OATP2A1, PGT, PHOAR2, SLC21A2, solute carrier organic anion transporter family member 2A1, PHOAD
External IDs	OMIM: 601460; MGI: 1346021; HomoloGene: 38077; GeneCards: SLCO2A1; OMA:SLCO2A1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q22.1-q22.2 Start 133,932,701 bp[1] End 134,052,184 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 F1|9 54.72 cM Start 102,865,911 bp[2] End 102,973,201 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung upper lobe of left lung right lobe of thyroid gland left lobe of thyroid gland lower lobe of lung seminal vesicula cardia left uterine tube gastric mucosa body of uterus Top expressed in decidua right lung gastrula endothelial cell of lymphatic vessel pyloric antrum left lung right lung lobe left lung lobe epithelium of stomach epithelium of small intestine More reference expression data BioGPS n/a
Gene ontology Molecular function transporter activity lipid transporter activity prostaglandin transmembrane transporter activity sodium-independent organic anion transmembrane transporter activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process lipid transport prostaglandin transport sodium-independent organic anion transport transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6578 24059 Ensembl ENSG00000174640 ENSMUSG00000032548 UniProt Q92959 Q9EPT5 RefSeq (mRNA) NM_005630 NM_033314 RefSeq (protein) NP_005621 NP_201571 Location (UCSC) Chr 3: 133.93 – 134.05 Mb Chr 9: 102.87 – 102.97 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanning organic anion-transporting polypeptide superfamily of transporters. The encoded protein may be involved in mediating the uptake and clearance of prostaglandins in numerous tissues.^[5]

Clinical relevance

Mutations in this gene have been shown to cause primary hypertrophic osteoarthropathy,^[6] specific form of chronic enteropathy.