PRB4

Basic salivary proline-rich protein 4 is a protein that in humans is encoded by the PRB4 gene.^[3]

PRB4
Identifiers
Aliases	PRB4, Po, proline-rich protein BstNI subfamily 4, proline rich protein BstNI subfamily 4
External IDs	OMIM: 180990; GeneCards: PRB4; OMA:PRB4 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.2 Start 11,307,077 bp[1] End 11,310,436 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory zone of nasal mucosa epithelium of colon tonsil bone marrow liver urinary bladder skin of abdomen skin of leg blood lymph node n/a More reference expression data BioGPS n/a
Gene ontology Molecular function molecular function Cellular component extracellular region Biological process biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5545 n/a Ensembl ENSG00000274839 ENSG00000230657 n/a UniProt P10163 n/a RefSeq (mRNA) NM_002723 NM_001261399 n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 12: 11.31 – 11.31 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

The protein encoded by this gene is a proline-rich salivary protein. This gene and five other genes that also encode salivary proline-rich proteins (PRPs), as well as a gene encoding a lacrimal gland PRP, form a PRP gene cluster in the chromosomal 12p13 region.^[3]

PRB4 is post-translationally cleaved into three different mature peptides:

• Protein N1
• Glycosylated protein A
• Peptide P-D (also known as proline-rich peptide IB-5)