THEMIS (protein)

THEMIS is a protein encoded by the eponymous THEMIS gene.^[5][6][7]

THEMIS
Identifiers
Aliases	THEMIS, C6orf190, C6orf207, GASP, SPOT, TSEPA, bA325O24.3, bA325O24.4, thymocyte selection associated, THEMIS (protein), IPR039671
External IDs	OMIM: 613607; MGI: 2443552; HomoloGene: 72287; GeneCards: THEMIS; OMA:THEMIS - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q22.33 Start 127,708,072 bp[1] End 127,918,631 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 A4 Start 28,544,356 bp[2] End 28,759,814 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lymph node granulocyte testicle appendix blood primary visual cortex epithelium of colon superior frontal gyrus prefrontal cortex tonsil Top expressed in thymus blood lymph node mesenteric lymph nodes oocyte subcutaneous adipose tissue primary oocyte secondary oocyte spleen zygote More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component cytoplasm COP9 signalosome nucleus cell-cell junction Biological process multicellular organism development T cell receptor signaling pathway adaptive immune response negative T cell selection positive T cell selection immune system process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 387357 210757 Ensembl ENSG00000275122 ENSG00000172673 ENSMUSG00000049109 UniProt Q8N1K5 Q8BGW0 RefSeq (mRNA) NM_001010923 NM_001164685 NM_001164687 NM_001318531 NM_001394520 NM_001394521 NM_001394522 NM_178666 NM_001305663 NM_001374699 RefSeq (protein) NP_001010923 NP_001158157 NP_001158159 NP_001305460 NP_001292592 NP_848781 NP_001361628 Location (UCSC) Chr 6: 127.71 – 127.92 Mb Chr 10: 28.54 – 28.76 Mb PubMed search [3] [4]
Wikidata
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Function

This protein plays a regulatory role in both positive and negative T cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells.^[8] Changes in THEMIS gene expression due to the rs138300818 variant promote the development of early-onset type 1 diabetes.^[9]

Etymology

THEMIS is an acronym for thymocyte-expressed molecule involved in selection. Themis is also the name of a Titan in Greek mythology who weighed the fates of humans, an apt choice since the protein is important in deciding the fate of the T cell during development.^[10]