Pseudomon-1 RNA motif

The Pseudomon-1 RNA motif is a conserved RNA identified by bioinformatics.^[1] It is used by most species whose genomes have been sequenced and that are classified within the genus Pseudomonas, and is also present in Azotobacter vinelandii, a closely related species. It is presumed to function as a non-coding RNA. Pseudomon-1 RNAs consistently have a downstream rho-independent transcription terminator.

Pseudomon-1 RNA
Consensus secondary structure of Pseudomon-1 RNAs
Identifiers
Symbol	Pseudomon-1
Rfam	RF01719
Other data
RNA type	sRNA
Domain	Pseudomonas
PDB structures	PDBe

The intergenic region containing Pseudomon-1 RNAs were also detected later by an independent study based on deep sequencing and called SPA0122^[2] The genes surrounding this region suggest a similarity to Spot 42 RNA,^[2] but the Pseudomonas RNA functions to regulate the AlgC enzyme^[3] Based on this information, the new name ErsA for the RNA was adopted.^[3] Negatively regulates major porin oprD expression responsible for uptake of carbapenem antibiotics, by base pairing with oprD 5′UTR (leading to increased bacterial resistance to meropenem).^[4] ErsA positively regulates amrZ mRNA and contributes to biofilm formation and motility.^[5]