Pseudouridimycin

Pseudouridimycin (PUM) is an experimental antibiotic isolated from the soil bacteria Streptomyces albus. It inhibits bacterial RNA polymerase through a different mechanism from previously discovered drugs. Pseudouridimycin shows useful activity against pathogens such as multidrug-resistant Streptococcus pyogenes, and while it is unclear whether it will be suitable for development for medical use in its own right, modified derivatives have been produced with improved stability and similar antibiotic properties.^{[1][2][3][4][5]}

Pseudouridimycin

Legal status
Legal status	Investigational
Identifiers
IUPAC name (2S)-2-[[2-(diaminomethylideneamino)acetyl]-hydroxyamino]-N-[[(2R,3S,4R,5S)-5-(2,4-dioxo-1H-pyrimidin-5-yl)-3,4-dihydroxyoxolan-2-yl]methyl]pentanediamide
CAS Number	1566586-52-4
PubChem CID	72792467
ChemSpider	59651398
ChEBI	CHEBI:199549
PDB ligand	PUM (PDBe, RCSB PDB)
Chemical and physical data
Formula	C17H26N8O9
Molar mass	486.442 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1=C(C(=O)NC(=O)N1)[C@H]2[C@@H]([C@@H]([C@H](O2)CNC(=O)[C@H](CCC(=O)N)N(C(=O)CN=C(N)N)O)O)O
InChI InChI=1S/C17H26N8O9/c18-9(26)2-1-7(25(33)10(27)5-22-16(19)20)15(31)21-4-8-11(28)12(29)13(34-8)6-3-23-17(32)24-14(6)30/h3,7-8,11-13,28-29,33H,1-2,4-5H2,(H2,18,26)(H,21,31)(H4,19,20,22)(H2,23,24,30,32)/t7-,8+,11+,12+,13-/m0/s1 Key:XDEYHXABZOKKDZ-YFKLLHAASA-N

See also

• Teixobactin
• Salbostatin