Pyridoxal phosphatase

The enzyme pyridoxal phosphatase^[1][2][3] (EC 3.1.3.74) catalyzes the reaction

pyridoxal 5′-phosphate + H₂O ${\displaystyle \rightleftharpoons }$ pyridoxal + phosphate

Pyridoxal phosphatase
Identifiers
EC no.	3.1.3.74
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

It also acts on pyridoxine phosphate (PNP), pyridoxamine phosphate (PMP), 4-pyridoxic acid phosphate and 4-deoxypyridoxine phosphate to remove their phosphate groups. Two human genes produce proteins that act as this kind of enzyme: PDXP and PHOSPHO2.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is pyridoxal-5′-phosphate phosphohydrolase. Other names in common use include vitamine B₆ (pyridoxine) phosphatase, PLP phosphatase, vitamin B₆-phosphate phosphatase, and PNP phosphatase. This enzyme participates in vitamin B₆ metabolism.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 2CFR, 2CFS, 2CFT, 2OYC, 2P27, and 2P69.