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Pyrimidine analogue
Chemicals that inhibit the use of a metabolite From Wikipedia, the free encyclopedia
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Pyrimidine analogues are antimetabolites which mimic the structure of metabolic pyrimidines.
 | This article needs additional citations for verification. (July 2013) |
Examples
- Nucleobase analogues
- Fluorouracil (5FU), which inhibits thymidylate synthase
- Floxuridine (FUDR)
- 6-azauracil (6-AU)
- Nucleoside analogues
- Cytarabine (Cytosine arabinoside)
- Gemcitabine
- Nucleotide analogues
Medical uses
Pyrimidine antimetabolites are commonly used to treat cancer by interfering with DNA replication.[1]
References
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