Pyrimidinylpiperazine

Pyrimidinylpiperazine
Names
	Preferred IUPAC name 2-(Piperazin-1-yl)pyrimidine
Identifiers
CAS Number	20980-22-7 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:166562;
ChEMBL	ChEMBL724 ;
ChemSpider	80080 ;
ECHA InfoCard	100.040.107
EC Number	244-135-5;
PubChem CID	88747;
UNII	H3B5B38F56;
CompTox Dashboard (EPA)	DTXSID00864967 ;
	InChI InChI=1S/C8H12N4/c1-2-10-8(11-3-1)12-6-4-9-5-7-12/h1-3,9H,4-7H2 Key: MRBFGEHILMYPTF-UHFFFAOYSA-N ; InChI=1S/C8H12N4/c1-2-10-8(11-3-1)12-6-4-9-5-7-12/h1-3,9H,4-7H2; InChI=1S/C8H12N4/c1-2-10-8(11-3-1)12-6-4-9-5-7-12/h1-3,9H,4-7H2 Key: MRBFGEHILMYPTF-UHFFFAOYSA-N;
	SMILES n1cccnc1N2CCNCC2;
Properties
Chemical formula	C8H12N4
Molar mass	164.21 g/mol
Hazards
	GHS labelling:
Pictograms
Signal word	Danger
Hazard statements	H314, H315, H319, H335
Precautionary statements	P260, P261, P264, P271, P280, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P332+P313, P337+P313, P362, P363, P403+P233, P405, P501
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

1-(2-Pyrimidinyl)piperazine (1-PP, 1-PmP) is a chemical compound and piperazine derivative. It is known to act as an antagonist of the α₂-adrenergic receptor (K_i = 7.3–40 nM)^[1] and, to a much lesser extent, as a partial agonist of the 5-HT_1A receptor (K_i = 414 nM; E_max = 54%).^[2]^[3] It has negligible affinity for the dopamine D₂, D₃, and D₄ receptors (K_i > 10,000 nM) and does not appear to have significant affinity for the α₁-adrenergic receptors.^[4]^{[additional citation(s) needed]} Its crystal structure has been determined.^[5]

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