Pyroglutamyl-peptidase II

Pyroglutamyl-peptidase II (EC 3.4.19.6, thyroliberinase, pyroglutamyl aminopeptidase II, thyrotropin-releasing factor pyroglutamate aminopeptidase, pyroglutamate aminopeptidase II, pyroglutamyl peptidase II, thyroliberin-hydrolyzing pyroglutamate aminopeptidase, thyrotropin-releasing hormone-degrading pyroglutamate aminopeptidase, thyrotropin-releasing hormone-degrading peptidase, TRH aminopeptidase) is an enzyme.^[1][2][3] This enzyme catalyses the following chemical reaction

Release of the N-terminal pyroglutamyl group from pGlu--His-Xaa tripeptides and pGlu--His-Xaa-Gly tetrapeptides

Pyroglutamyl-peptidase II
Identifiers
EC no.	3.4.19.6
CAS no.	60063-88-9
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

This enzyme is highly specific for thyrotropin releasing hormone.

Human gene

TRHDE - thyrotropin releasing hormone degrading enzyme