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Pyrovalerone

Chemical compound From Wikipedia, the free encyclopedia

Pyrovalerone
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Pyrovalerone (Centroton, 4-Methyl-β-keto-prolintane, Thymergix, O-2371)[2] is a central nervous system (CNS) stimulant that acts as a norepinephrine–dopamine reuptake inhibitor (NDRI). It was developed in the 1980s and had briefly been approved in Spain and France for chronic fatigue or lethargy[3] and as an appetite suppressant, but was withdrawn from both markets around 2001 due to safety concerns including problems with abuse and dependence.[4] It is closely related on a structural level to a number of other cathinone stimulants, such as α-PVP, MDPV and prolintane.

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Side effects of pyrovalerone include decreased appetite, anxiety, fragmented sleep or insomnia, and trembling, shaking, or muscle tremors. Withdrawal symptoms following abuse upon discontinuation often results in depression.

The R-enantiomer of pyrovalerone is devoid of pharmacologic activity.[5]

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