Q-type calcium channel

The Q-type calcium channel is a type of voltage-dependent calcium channel. Like the others of this class, the α1 subunit is the one that determines most of the channel's properties.

calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Identifiers
Symbol	CACNA1A
Alt. symbols	CACNL1A4, SCA6, MHP1, MHP
IUPHAR	532
NCBI gene	773
HGNC	1388
OMIM	601011
RefSeq	NM_000068
UniProt	O00555
Other data
Locus	Chr. 19 p13
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They are poorly understood, but like R-type calcium channels, they appear to be present in cerebellar granule cells. They have a high threshold of activation and relatively slow kinetics.

Mutations in the CACNA1A gene that encodes this protein are responsible for familial hemiplegic migraine type 1 (FHM1), episodic ataxia type 2 (EA2) and spinocerebellar ataxia type 6 (SCA6).^[1]