Quinolinate synthase

Quinolinate synthase (EC 2.5.1.72, NadA, QS, quinolinate synthetase) is an enzyme with systematic name glycerone phosphate:iminosuccinate alkyltransferase (cyclizing).^{[1][2][3][4][5]} This enzyme catalyses the following chemical reaction

glycerone phosphate + iminosuccinate ${\displaystyle \rightleftharpoons }$ pyridine-2,3-dicarboxylate + 2 H₂O + phosphate

Quinolinate synthase
Identifiers
EC no.	2.5.1.72
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
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This iron-sulfur protein that requires a [4Fe-4S] cluster for activity.