Retinoic acid receptor gamma

Retinoic acid receptor gamma (RAR-γ), also known as NR1B3 (nuclear receptor subfamily 1, group B, member 3) is a nuclear receptor encoded by the RARG gene.^[5][6] Adapalene selectively targets retinoic acid receptor beta and retinoic acid receptor gamma^[7] and its agonism of the gamma subtype is largely responsible for adapalene's observed effects.^[8]

RARG
Available structures PDB Ortholog search: H3BMH6 PDBe H3BMH6 RCSB List of PDB id codes 1EXA, 1EXX, 1FCX, 1FCY, 1FCZ, 1FD0, 2LBD, 3LBD, 4LBD
Identifiers
Aliases	RARG, NR1B3, RARC, retinoic acid receptor gamma, RARgamma
External IDs	OMIM: 180190; MGI: 97858; HomoloGene: 20263; GeneCards: RARG; OMA:RARG - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.13 Start 53,210,567 bp[1] End 53,232,980 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 F2|15 57.4 cM Start 102,143,373 bp[2] End 102,165,952 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of leg skin of abdomen stromal cell of endometrium ectocervix canal of the cervix right coronary artery vagina right uterine tube apex of heart tibial nerve Top expressed in axial skeleton lip human vertebral column bones of pectoral girdle sacrum shoulder cervical vertebral column tail of embryo ankle vertebra More reference expression data BioGPS n/a
Gene ontology Molecular function sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding zinc ion binding metal ion binding steroid hormone receptor activity protein binding DNA-binding transcription factor activity DNA binding retinoid X receptor binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription cis-regulatory region binding transcription factor binding nuclear receptor coactivator activity signaling receptor activity nuclear receptor activity Cellular component integral component of membrane nucleoplasm nucleus transcription regulator complex RNA polymerase II transcription regulator complex Biological process regulation of cell size growth plate cartilage development cellular response to retinoic acid gland development regulation of transcription, DNA-templated negative regulation of cartilage development response to retinoic acid multicellular organism growth negative regulation of cell differentiation bone morphogenesis chondrocyte development negative regulation of apoptotic process retinal pigment epithelium development transcription, DNA-templated epithelium development embryonic camera-type eye development reproductive structure development limb development face development neural tube closure negative regulation of chondrocyte differentiation Harderian gland development prostate gland epithelium morphogenesis regulation of myelination positive regulation of gene expression retina development in camera-type eye positive regulation of cell population proliferation growth plate cartilage chondrocyte growth canonical Wnt signaling pathway regulation of gene expression camera-type eye development transcription initiation from RNA polymerase II promoter regulation of myeloid cell differentiation bone development trachea cartilage development anterior/posterior pattern specification glandular epithelial cell development steroid hormone mediated signaling pathway negative regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II embryonic hindlimb morphogenesis retinoic acid receptor signaling pathway negative regulation of cell population proliferation embryonic eye morphogenesis positive regulation of apoptotic process positive regulation of programmed cell death cellular response to leukemia inhibitory factor multicellular organism development hormone-mediated signaling pathway cell differentiation response to lipid Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5916 19411 Ensembl ENSG00000172819 ENSMUSG00000001288 UniProt P13631 P18911 RefSeq (mRNA) NM_000966 NM_001042728 NM_001243730 NM_001243731 NM_001243732 NM_001042727 NM_011244 RefSeq (protein) NP_000957 NP_001036193 NP_001230659 NP_001230660 NP_001230661 NP_001036192 NP_035374 Location (UCSC) Chr 12: 53.21 – 53.23 Mb Chr 15: 102.14 – 102.17 Mb PubMed search [3] [4]
Wikidata
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Interactions

Retinoic acid receptor gamma has been shown to interact with NCOR1.^[9]

See also

• Retinoic acid receptor