RNA binding motif protein, Y-linked, family 1, member A1

RNA-binding motif protein, Y chromosome, family 1 member A1/C is a protein that in humans is encoded by the RBMY1A1 gene.^[3][4][5]

RBMY1A1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2FY1
Identifiers
Aliases	RBMY1A1, RBM, RBM1, RBM2, RBMY, RBMY1C, YRRM1, YRRM2, RNA binding motif protein, Y-linked, family 1, member A1, RNA binding motif protein Y-linked family 1 member A1
External IDs	OMIM: 400006; HomoloGene: 121598; GeneCards: RBMY1A1; OMA:RBMY1A1 - orthologs
Gene location (Human) Chr. Y chromosome (human)[1] Band Yq11.223 Start 21,511,372 bp[1] End 21,549,326 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad right testis left testis human kidney renal cortex placenta canal of the cervix fundus blood n/a More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding mRNA binding RNA binding nucleic acid binding Cellular component nucleus nuclear speck Biological process mRNA processing regulation of alternative mRNA splicing, via spliceosome RNA splicing mRNA cis splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5940 n/a Ensembl ENSG00000234414 n/a UniProt P0DJD3 n/a RefSeq (mRNA) NM_005058 NM_001320944 NM_001320945 n/a RefSeq (protein) NP_001307873 NP_001307874 NP_005049 NP_001006120 NP_001307878 NP_001307879 n/a Location (UCSC) Chr Y: 21.51 – 21.55 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. Multiple copies of this gene are found in the AZFb azoospermia factor region of chromosome Y and the encoded protein is thought to be involved in spermatogenesis. Most copies of this locus are pseudogenes, although six highly similar copies have full-length ORFs and are considered functional. Four functional copies of this gene are found within inverted repeat IR2; two functional copies of this gene are found in palindrome P3, along with two copies of PTPN13-like, Y-linked. Alternative splicing of transcripts results in two transcript variants that encode different proteins.^[5]