Reticulocalbin 1

Reticulocalbin-1 is a protein that in humans is encoded by the RCN1 gene.^[5][6][7]

RCN1
Identifiers
Aliases	RCN1, HEL-S-84, PIG20, RCAL, RCN, reticulocalbin 1
External IDs	OMIM: 602735; MGI: 104559; HomoloGene: 20637; GeneCards: RCN1; OMA:RCN1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p13 Start 32,091,074 bp[1] End 32,105,722 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 E3|2 55.18 cM Start 105,216,636 bp[2] End 105,229,664 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis stromal cell of endometrium ventricular zone cartilage tissue periodontal fiber seminal vesicula tendon of biceps brachii right coronary artery tibia caput epididymis Top expressed in seminal vesicula vestibular sensory epithelium gastrula parotid gland umbilical cord dermis utricle atrium human fetus calvaria More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding protein binding metal ion binding Cellular component endoplasmic reticulum lumen endoplasmic reticulum Biological process post-translational protein modification in utero embryonic development camera-type eye development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5954 19672 Ensembl ENSG00000049449 ENSMUSG00000005973 UniProt Q15293 Q05186 RefSeq (mRNA) NM_002901 NM_009037 RefSeq (protein) NP_002892 NP_033063 Location (UCSC) Chr 11: 32.09 – 32.11 Mb Chr 2: 105.22 – 105.23 Mb PubMed search [3] [4]
Wikidata
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Reticulocalbin 1 is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. High conservation of amino acid residues outside of these motifs, in comparison to mouse reticulocalbin, is consistent with a possible biochemical function besides that of calcium binding.^[7]