Repulsive guidance molecule B

Repulsive guidance molecule B (RGMb), also known as DRAGON (DRG11-responsive axonal guidance and outgrowth of neurite), is a bone morphogenetic protein (BMP) co-receptor of the repulsive guidance molecule family.^[5] In humans this protein is encoded by the RGMB gene.^[6]

RGMB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4BQ6, 4BQ7, 4BQ8, 4UHZ, 4UI0, 4UI2
Identifiers
Aliases	RGMB, DRAGON, repulsive guidance molecule family member b, repulsive guidance molecule BMP co-receptor b
External IDs	OMIM: 612687; MGI: 1916049; HomoloGene: 65355; GeneCards: RGMB; OMA:RGMB - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q15 Start 98,768,650 bp[1] End 98,798,643 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 A2 Start 15,803,188 bp[2] End 15,831,039 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum pylorus skin of arm skin of thigh tibialis anterior muscle cardia cardiac muscle tissue of right atrium rectum deltoid muscle spinal ganglia Top expressed in Rostral migratory stream otolith organ utricle Paneth cell lateral habenular nucleus paraventricular nucleus of thalamus medial habenular nucleus spinal ganglia lumbar spinal ganglion sciatic nerve More reference expression data BioGPS n/a
Gene ontology Molecular function coreceptor activity identical protein binding protein binding Cellular component membrane raft anchored component of membrane plasma membrane membrane endoplasmic reticulum-Golgi intermediate compartment anchored component of plasma membrane Biological process positive regulation of transcription, DNA-templated signal transduction BMP signaling pathway cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 285704 68799 Ensembl ENSG00000174136 ENSMUSG00000048027 UniProt Q6NW40 Q7TQ33 RefSeq (mRNA) NM_001012761 NM_173670 NM_001366508 NM_001366509 NM_001366510 NM_001366511 NM_178615 RefSeq (protein) NP_001012779 NP_001353437 NP_001353438 NP_001353439 NP_001353440 NP_848730 Location (UCSC) Chr 5: 98.77 – 98.8 Mb Chr 17: 15.8 – 15.83 Mb PubMed search [3] [4]
Wikidata
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Function

RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family (see also RGMA and RGMC) and contributes to the patterning of the developing nervous system.^[7][8]

There is a potential association between RGMs and cancer bone metastasis, as RGMs coordinate bone morphogenetic protein (BMP) signaling. RGMB may act as a negative regulator in vitro in breast cancer and prostate cancer through BMP signalling.^[9][10] Furthermore, aberrant expression of RGMs was indicated in breast cancer. The perturbed expression was associated with disease progression and poor prognosis.^[11]