RNAI

For RNA interference, see RNAi.

RNAI is a non-coding RNA that is an antisense repressor of the replication of some E. coli plasmids, including ColE1. Plasmid replication is usually initiated by RNAII,^[1] which acts as a primer by binding to its template DNA. The complementary RNAI binds RNAII prohibiting it from its initiation role. The rate of degradation of RNAI is therefore a major factor in the control of plasmid replication. This rate of degradation is aided by the pcnB (plasmid copy number B) gene product,^[2] which polyadenylates the 3' end of RNAI targeting it for degradation by PNPase.^[3]

RNAI
Predicted secondary structure and sequence conservation of RNAI
Identifiers
Symbol	RNAI
Rfam	RF00106
Other data
RNA type	Gene; antisense
Domain(s)	Bacteria
SO	SO:0000644
PDB structures	PDBe