RAR-related orphan receptor beta

RAR-related orphan receptor beta (ROR-beta), also known as NR1F2 (nuclear receptor subfamily 1, group F, member 2) is a nuclear receptor that in humans is encoded by the RORB gene.^[5]

RORB
Identifiers
Aliases	RORB, NR1F2, ROR-BETA, RZR-BETA, RZRB, bA133M9.1, RAR-related orphan receptor beta, RAR related orphan receptor B, EIG15
External IDs	OMIM: 601972; MGI: 1343464; HomoloGene: 38250; GeneCards: RORB; OMA:RORB - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q21.13 Start 74,497,335 bp[1] End 74,693,177 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 B Start 18,907,969 bp[2] End 19,088,560 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Brodmann area 23 middle temporal gyrus parietal lobe postcentral gyrus retinal pigment epithelium primary visual cortex superior frontal gyrus entorhinal cortex endometrium Top expressed in internal granular layer medial geniculate nucleus medial dorsal nucleus lateral geniculate nucleus Rostral migratory stream retina neural layer of retina retinal pigment epithelium lumbar subsegment of spinal cord posterior horn of spinal cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding DNA binding DNA-binding transcription factor activity zinc ion binding transcription factor binding metal ion binding steroid hormone receptor activity nuclear receptor activity protein binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific melatonin receptor activity Cellular component nucleoplasm nucleus Biological process cellular response to retinoic acid regulation of transcription, DNA-templated response to stimulus rhythmic process retinal cone cell development negative regulation of osteoblast differentiation transcription, DNA-templated positive regulation of transcription, DNA-templated multicellular organism development regulation of circadian rhythm retinal rod cell development eye photoreceptor cell development transcription initiation from RNA polymerase II promoter negative regulation of transcription, DNA-templated visual perception steroid hormone mediated signaling pathway intracellular receptor signaling pathway amacrine cell differentiation retina development in camera-type eye positive regulation of transcription by RNA polymerase II G protein-coupled receptor signaling pathway transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6096 225998 Ensembl ENSG00000198963 ENSMUSG00000036192 UniProt Q92753 Q58EY0 Q8R1B8 RefSeq (mRNA) NM_006914 NM_001365023 NM_001043354 NM_001289921 NM_146095 RefSeq (protein) NP_008845 NP_001351952 NP_001036819 NP_001276850 NP_666207 Location (UCSC) Chr 9: 74.5 – 74.69 Mb Chr 19: 18.91 – 19.09 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside-diphosphate kinase involved in organogenesis and differentiation.^[6]

In the brain, ROR-beta is concentrated in layer 4 of the cerebral cortex, where it plays a role in the development of structures such as barrel columns.^[7]

A mutation in this gene also results in the loss of spinal cord interneurons and of saltatorial locomotion,^[8] a type of hopping gait that in mammals can be found in rabbits, hares, kangaroos, and some species of rodents.

Interactions

RAR-related orphan receptor beta has been shown to interact with NME1.^[9]

See also

• RAR-related orphan receptor