60S ribosomal protein L10a

60S ribosomal protein L10a is a protein that in humans is encoded by the RPL10A gene.^[5][6][7]

RPL10A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5AJ0, 3J7R
Identifiers
Aliases	RPL10A, CSA19, Csa-19, L10A, NEDD6, ribosomal protein L10a, uL1
External IDs	OMIM: 615660; MGI: 1343877; HomoloGene: 68543; GeneCards: RPL10A; OMA:RPL10A - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.31 Start 35,468,401 bp[1] End 35,470,785 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 A3.3 Start 28,547,445 bp[2] End 28,550,007 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube left ovary right ovary canal of the cervix body of uterus smooth muscle tissue skin of abdomen left uterine tube skin of leg ganglionic eminence Top expressed in genital tubercle tail of embryo epiblast urinary bladder spleen thymus embryo ovary embryo uterus More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome protein binding RNA binding Cellular component cytosol ribosome membrane focal adhesion large ribosomal subunit extracellular exosome nucleus cytosolic large ribosomal subunit postsynaptic density polysomal ribosome Biological process viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay maturation of LSU-rRNA protein biosynthesis rRNA processing response to ethanol cytoplasmic translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4736 19896 Ensembl ENSG00000198755 ENSMUSG00000037805 UniProt P62906 P53026 RefSeq (mRNA) NM_007104 NM_011287 NM_001357628 RefSeq (protein) NP_009035 n/a Location (UCSC) Chr 6: 35.47 – 35.47 Mb Chr 17: 28.55 – 28.55 Mb PubMed search [3] [4]
Wikidata
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Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L1P family of ribosomal proteins. It is located in the cytoplasm. The expression of this gene is downregulated in the thymus by cyclosporin-A (CsA), an immunosuppressive drug. Studies in mice have shown that the expression of the ribosomal protein L10a gene is downregulated in neural precursor cells during development. This gene used to be referred to as NEDD6 (neural precursor cell expressed, developmentally downregulated 6), but it has been renamed RPL10A (ribosomal protein 10a). As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[7]