60S ribosomal protein L17

Large ribosomal subunit protein uL22 is a protein that in humans is encoded by the RPL17 gene.^[5][6][7]

RPL17
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5AJ0, 4V5Z, 4UJD, 5A8L, 4D67, 3J92, 4D5Y, 4UJE, 4UJC
Identifiers
Aliases	RPL17, L17, PD-1, RPL23, ribosomal protein L17
External IDs	OMIM: 603661; MGI: 2448270; HomoloGene: 115574; GeneCards: RPL17; OMA:RPL17 - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q21.1 Start 49,488,453 bp[1] End 49,492,523 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 E3 Start 75,131,629 bp[2] End 75,136,452 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ovary right ovary right uterine tube endometrium anterior pituitary body of uterus Achilles tendon left lobe of thyroid gland body of pancreas canal of the cervix Top expressed in uterus ventricular zone epiblast spleen thymus ganglionic eminence lens zone of skin pancreas bone marrow More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding structural constituent of ribosome RNA binding Cellular component cytosol ribosome large ribosomal subunit intracellular anatomical structure cytosolic large ribosomal subunit nucleus Biological process viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay rRNA processing protein biosynthesis cytoplasmic translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6139 319195 Ensembl ENSG00000265681 ENSMUSG00000062328 UniProt P18621 Q9CPR4 Q6ZWZ7 RefSeq (mRNA) NM_001199345 NM_000985 NM_001035006 NM_001199340 NM_001199341 NM_001199342 NM_001199343 NM_001199344 NM_001002239 RefSeq (protein) NP_000976 NP_001030178 NP_001186269 NP_001186270 NP_001186271 NP_001186272 NP_001186273 NP_001186274 NP_001356484 NP_001356485 NP_001356486 NP_001356487 NP_001356489 NP_001356490 NP_001356491 NP_001356492 NP_001002239 NP_001392893 NP_001392894 NP_001392895 Location (UCSC) Chr 18: 49.49 – 49.49 Mb Chr 18: 75.13 – 75.14 Mb PubMed search [3] [4]
Wikidata
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Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22P family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as RPL23 because the encoded protein shares amino acid identity with ribosomal protein L23 from Haloarcula marismortui; however, its official symbol is RPL17. Two alternative splice variants have been observed, each encoding the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[7]

See also

• Mitochondrial ribosomal protein L22, another human protein of uL22 (L22p or L17e) family