60S ribosomal protein L21

60S ribosomal protein L21 is a protein that in humans is encoded by the RPL21 gene.^[5][6][7]

RPL21
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5AJ0, 3J7R, 4UJD, 3J7P, 4D67, 3J92, 4D5Y, 3J7Q, 4UJE, 3J7O, 4UJC
Identifiers
Aliases	RPL21, HYPT12, L21, ribosomal protein L21
External IDs	OMIM: 603636; MGI: 1278340; HomoloGene: 128048; GeneCards: RPL21; OMA:RPL21 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q12.2 Start 27,251,362 bp[1] End 27,256,691 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G3 Start 146,769,700 bp[2] End 146,773,842 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon ganglionic eminence primary visual cortex epithelium of colon endometrium lymph node ventricular zone white blood cell monocyte superior frontal gyrus Top expressed in ovary urinary bladder ventricular zone ganglionic eminence lens zone of skin uterus adrenal gland esophagus ileum More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding RNA binding structural constituent of ribosome Cellular component cytosol ribosome membrane intracellular anatomical structure cytosolic large ribosomal subunit cytoplasm endoplasmic reticulum Biological process viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay rRNA processing protein biosynthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6144 19933 Ensembl ENSG00000122026 ENSMUSG00000041453 UniProt P46778 O09167 Q9CQM8 RefSeq (mRNA) NM_000982 NM_019647 RefSeq (protein) NP_000973 NP_062621 Location (UCSC) Chr 13: 27.25 – 27.26 Mb Chr 5: 146.77 – 146.77 Mb PubMed search [3] [4]
Wikidata
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Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L21E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[7]

Clinical relevance

Mutations in the RPL21 gene result in Hypotrichosis simplex of the scalp.^[8]