60S ribosomal protein L6

60S ribosomal protein L6 is a protein that in humans is encoded by the RPL6 gene.^[4][5][6]

RPL6
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5AJ0, 4D67, 4D5Y, 4UJE
Identifiers
Aliases	RPL6, L6, SHUJUN-2, TAXREB107, TXREB1, ribosomal protein L6
External IDs	OMIM: 603703; MGI: 3647789; HomoloGene: 31001; GeneCards: RPL6; OMA:RPL6 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.13 Start 112,405,189 bp[1] End 112,418,838 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone gonad islet of Langerhans pituitary gland Achilles tendon lymph node left ovary smooth muscle tissue monocyte n/a More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding structural constituent of ribosome cadherin binding RNA binding Cellular component cytosol ribosome membrane focal adhesion intracellular anatomical structure cytoplasmic ribonucleoprotein granule cytosolic large ribosomal subunit nucleus cytoplasm endoplasmic reticulum rough endoplasmic reticulum postsynaptic density polysomal ribosome synapse Biological process cytoplasmic translation regulation of transcription, DNA-templated protein biosynthesis viral transcription SRP-dependent cotranslational protein targeting to membrane ribosomal large subunit assembly translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay rRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6128 432502 Ensembl ENSG00000089009 n/a UniProt Q02878 n/a RefSeq (mRNA) NM_000970 NM_001024662 NM_001320137 NM_001320138 NM_001320139 NM_001320140 NM_001320141 NM_001320142 XM_036156129 RefSeq (protein) NP_000961 NP_001019833 NP_001307066 NP_001307067 NP_001307068 NP_001307069 NP_001307070 NP_001307071 n/a Location (UCSC) Chr 12: 112.41 – 112.42 Mb n/a PubMed search [2] [3]
Wikidata
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Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L6E family of ribosomal proteins. It is located in the cytoplasm. The protein can bind specifically to domain C of the tax-responsive enhancer element of human T-cell leukemia virus type 1, and it has been suggested that the protein may participate in tax-mediated transactivation of transcription. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.^[6]

Interactions

RPL6 has been shown to interact with Basic fibroblast growth factor.^[7]