40S ribosomal protein S12

40S ribosomal protein S12 is a protein that in humans is encoded by the RPS12 gene.^[5][6][7]

RPS12
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4V6X, 5A2Q, 5AJ0, 4KZY, 4D61, 5FLX, 4KZX, 4D5L, 4UJD, 4KZZ, 4UJE, 4UJC
Identifiers
Aliases	RPS12, S12, ribosomal protein S12
External IDs	OMIM: 603660; MGI: 98105; HomoloGene: 110750; GeneCards: RPS12; OMA:RPS12 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q23.2 Start 132,814,569 bp[1] End 132,817,564 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 A4 Start 23,661,081 bp[2] End 23,663,173 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ovary right ovary gonad lymph node skin of abdomen canal of the cervix skin of leg ectocervix granulocyte right uterine tube Top expressed in medial ganglionic eminence lip efferent ductule ventricular zone endocardial cushion embryo embryo dermis atrioventricular valve epiblast More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of ribosome RNA binding Cellular component ribosome cytoplasm membrane intracellular anatomical structure cytosolic small ribosomal subunit nucleoplasm cytosol Golgi apparatus intracellular membrane-bounded organelle Biological process SRP-dependent cotranslational protein targeting to membrane viral transcription nuclear-transcribed mRNA catabolic process, nonsense-mediated decay translational initiation protein biosynthesis rRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6206 20042 Ensembl ENSG00000112306 ENSMUSG00000061983 UniProt P25398 P63323 Q6ZWZ6 RefSeq (mRNA) NM_001016 NM_011295 RefSeq (protein) NP_001007 NP_035425 Location (UCSC) Chr 6: 132.81 – 132.82 Mb Chr 10: 23.66 – 23.66 Mb PubMed search [3] [4]
Wikidata
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Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S12E family of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal cancers compared to matched normal colonic mucosa has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[7]