R-spondin 3

R-spondin-3 is a protein that in humans is encoded by the RSPO3 gene.^[5][6][7]

RSPO3
Identifiers
Aliases	RSPO3, CRISTIN1, PWTSR, THSD2, R-spondin 3
External IDs	OMIM: 610574; MGI: 1920030; HomoloGene: 12484; GeneCards: RSPO3; OMA:RSPO3 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q22.33 Start 127,118,671 bp[1] End 127,199,481 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 A4 Start 29,328,412 bp[2] End 29,411,863 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastric mucosa tail of epididymis caput epididymis smooth muscle tissue corpus epididymis vastus lateralis muscle superficial temporal artery buccal mucosa cell placenta body of uterus Top expressed in vas deferens otolith organ tail of embryo utricle vestibular sensory epithelium primitive streak stria vascularis stroma of bone marrow adventitia of seminal vesicle gastrula More reference expression data BioGPS n/a
Gene ontology Molecular function heparin binding signaling receptor binding frizzled binding Cellular component extracellular region extracellular space Biological process positive regulation of canonical Wnt signaling pathway positive regulation of Wnt signaling pathway positive regulation of Wnt signaling pathway, planar cell polarity pathway Wnt signaling pathway branching involved in labyrinthine layer morphogenesis angiogenesis response to stimulus blood vessel remodeling positive regulation of non-canonical Wnt signaling pathway sprouting angiogenesis regulation of Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84870 72780 Ensembl ENSG00000146374 ENSMUSG00000019880 UniProt Q9BXY4 Q2TJ95 RefSeq (mRNA) NM_032784 NM_028351 RefSeq (protein) NP_116173 NP_082627 Location (UCSC) Chr 6: 127.12 – 127.2 Mb Chr 10: 29.33 – 29.41 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the thrombospondin type 1 repeat gene superfamily. In addition, the protein contains a furin-like cysteine-rich region. Furin-like repeat domains have been found in a variety of eukaryotic proteins involved in the mechanism of signal transduction by receptor tyrosine kinases.^[7]

During embryonic development, RSPO3 is expressed in the tail bud and the posterior presomitic mesoderm of the embryo. In tissue engineering, R-spondin 3 has been used to differentiate pluripotent stem cells into paraxial mesoderm progenitors^[8]