RU-58642

RU-58642
Clinical data
Drug class	Nonsteroidal antiandrogen
Identifiers
	IUPAC name 4-[3-(cyanomethyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile;
CAS Number	143782-63-2 ;
PubChem CID	9840708;
ChemSpider	8016425;
UNII	DX44GS85HK;
CompTox Dashboard (EPA)	DTXSID50162546 ;
Chemical and physical data
Formula	C15H11F3N4O2
Molar mass	336.274 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C1N(CC#N)C(C)(C)C(=O)N1c(cc2C(F)(F)F)ccc2C#N;
	InChI InChI=1S/C15H11F3N4O2/c1-14(2)12(23)22(13(24)21(14)6-5-19)10-4-3-9(8-20)11(7-10)15(16,17)18/h3-4,7H,6H2,1-2H3; Key:ZVWXHSNUBLIKJH-UHFFFAOYSA-N;

RU-58642 is a nonsteroidal antiandrogen (NSAA) derived from nilutamide with very high affinity and selectivity for the androgen receptor (AR), which made it among the most potent and efficacious antiandrogens known at the time of its discovery.^[1] It was investigated for topical application for the treatment of androgenetic alopecia (male-pattern baldness), but development did not proceed past initial trial stages, and it is now only used for scientific research into the AR.^[2]^[3]

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See also