Ryanodine receptor 3

Ryanodine receptor 3 is one of a class of ryanodine receptors and a protein that in humans is encoded by the RYR3 gene.^[5] The protein encoded by this gene is both a calcium channel and a receptor for the plant alkaloid ryanodine. RYR3 and RYR1 control the resting calcium ion concentration in skeletal muscle.^[6]

RYR3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4ERV
Identifiers
Aliases	RYR3, RYR-3, ryanodine receptor 3
External IDs	OMIM: 180903; MGI: 99684; HomoloGene: 68151; GeneCards: RYR3; OMA:RYR3 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q13.3-q14 Start 33,310,962 bp[1] End 33,866,121 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E3- E4 Start 112,461,700 bp[2] End 113,047,441 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thoracic diaphragm sural nerve right hemisphere of cerebellum caudate nucleus putamen right uterine tube nucleus accumbens right frontal lobe body of uterus gastrocnemius muscle Top expressed in olfactory tubercle lateral septal nucleus medial dorsal nucleus subiculum mammillary body nucleus accumbens motor neuron lateral geniculate nucleus globus pallidus substantia nigra More reference expression data BioGPS n/a
Gene ontology Molecular function ryanodine-sensitive calcium-release channel activity calcium channel activity calcium-release channel activity calmodulin binding ion channel activity calcium-induced calcium release activity calcium ion binding Cellular component organelle membrane integral component of membrane membrane intracellular membrane-bounded organelle sarcoplasmic reticulum sarcoplasmic reticulum membrane endoplasmic reticulum perinuclear region of cytoplasm plasma membrane smooth endoplasmic reticulum Z discdkac cytoplasmic vesicle membrane calcium channel complex sarcolemma Biological process cellular response to calcium ion cellular response to magnesium ion regulation of cardiac conduction cellular calcium ion homeostasis ion transport ion transmembrane transport calcium ion transmembrane transport cellular response to caffeine cellular response to ATP protein homotetramerization calcium ion transport negative regulation of cytosolic calcium ion concentration transmembrane transport release of sequestered calcium ion into cytosol Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6263 20192 Ensembl ENSG00000198838 ENSMUSG00000057378 UniProt Q15413 A2AGL3 RefSeq (mRNA) NM_001036 NM_001243996 NM_177652 NM_001319156 RefSeq (protein) NP_001027 NP_001230925 NP_001306085 Location (UCSC) Chr 15: 33.31 – 33.87 Mb Chr 2: 112.46 – 113.05 Mb PubMed search [3] [4]
Wikidata
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See also

• Ryanodine receptor