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Ramatroban

Chemical compound From Wikipedia, the free encyclopedia

Ramatroban
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Ramatroban (INN; also known as BAY u3405)[1] is a thromboxane receptor antagonist.[2] It is also a DP2 receptor antagonist.[3]

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Ramatroban is indicated for the treatment of coronary artery disease.[4] It has also been used for the treatment of asthma.[5]

It has been suggested that ramatroban, by modulating DP2 receptor, can reverse viremia-associated proinflammatory and prothrombotic processes which are similar to those induced by SARS-Cov-2.[citation needed] Hence, ramatroban, that has been used for the treatment of allergic rhinitis in Japan for the past two decades with a well established safety profile, merits investigation as a novel immunotherapy for the treatment of COVID-19 disease, although no clinical trial has yet been conducted.[6]

Ramatroban was developed by the German pharmaceutical company Bayer AG and is co-marketed in Japan by Bayer Yakuhin then marketed by Kyorin Pharmaceutical and Nippon Shinyaku Co., Ltd. under the trade name Baynas.

It is a tetrahydrocarbazolamine derivative and cyclized tryptamine.

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