Rauwolscine

Rauwolscine, also known as isoyohimbine, α-yohimbine, and corynanthidine, is an alkaloid found in various species within the genera Rauvolfia and Corynanthe (including Pausinystalia).^[1] It is a stereoisomer of yohimbine.^[1] Rauwolscine is a central nervous system stimulant, a local anesthetic and a vague aphrodisiac.^[1]

Rauwolscine

Clinical data
Other names	Isoyohimbine, α-yohimbine, corynanthidine
Routes of administration	Oral
ATC code	none
Legal status
Legal status	In general: uncontrolled
Identifiers
IUPAC name 17α-hydroxy-20α-yohimban-16β-carboxylic acid methyl ester
CAS Number	131-03-3 N 6211-32-1 (HCl)
PubChem CID	643606
IUPHAR/BPS	136
ChemSpider	558737 Y
UNII	T4LJ7LU45W
ChEBI	CHEBI:48562 Y
ChEMBL	ChEMBL10347 Y
CompTox Dashboard (EPA)	DTXSID2045608
ECHA InfoCard	100.004.553
Chemical and physical data
Formula	C21H26N2O3
Molar mass	354.450 g·mol−1
InChI InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15+,17+,18+,19+/m1/s1 Y Key:BLGXFZZNTVWLAY-DIRVCLHFSA-N Y
NY (what is this?)  (verify)

Rauwolscine acts predominantly as a α₂-adrenergic receptor antagonist.^[2][3] It has also been shown to function as a 5-HT_1A receptor partial agonist and 5-HT_2A and 5-HT_2B receptor antagonist.^[4][5][6]

See also

• Ajmalicine
• Corynanthine
• Spegatrine