Reactive carbonyl species

Reactive carbonyl species (RCS) are molecules with highly reactive carbonyl groups, and often known for their damaging effects on proteins, nucleic acids, and lipids. They are often generated as metabolic products. Important RCSs include 3-deoxyglucosone, glyoxal, and methylglyoxal. RCSs react with amines and thiol groups leading to advanced glycation endproducts (AGEs). AGE's are indicators of diabetes.^[1]

3-Deoxyglucosone, a common RCS, rapidly reacts with protein amino groups to form AGEs.

Reactive aldehyde species (RASP),^[2] such as malondialdehyde and 4-hydroxynonenal, are a subset of RCS that are implicated in a variety of human diseases.^[3]

See also

• Reactive oxygen species
• Reactive sulfur species
• Reactive nitrogen species