Rebamipide

Rebamipide, an amino acid derivative of 2-(1H)-quinolinone, is used for mucosal protection,^[1] healing of gastroduodenal ulcers, and treatment of gastritis.^[2] It works by enhancing mucosal defense, scavenging free radicals,^[3] and temporarily activating genes encoding cyclooxygenase-2.^[4]

Rebamipide

Clinical data
Trade names	Mucosta (JP), Rebagen (KR, CN, IN), Rebagit (RU), Ramiper, Rebamax (ID)
AHFS/Drugs.com	International Drug Names
Routes of administration	By mouth (tablets)
ATC code	A02BX14 (WHO)
Identifiers
IUPAC name 2-[(4-chlorobenzoyl)amino]-3-(2-oxo-1H-quinolin-4-yl)propanoic acid
CAS Number	90098-04-7 N
PubChem CID	5042
IUPHAR/BPS	871
DrugBank	DB11656 Y
ChemSpider	4866 Y
UNII	LR583V32ZR
KEGG	D01121 Y
ChEMBL	ChEMBL1697771 N
CompTox Dashboard (EPA)	DTXSID8045937
Chemical and physical data
Formula	C19H15ClN2O4
Molar mass	370.79 g·mol−1
3D model (JSmol)	Interactive image
SMILES Clc1ccc(cc1)C(=O)NC(C(=O)O)CC2=CC(=O)Nc3ccccc32
InChI InChI=1S/C19H15ClN2O4/c20-13-7-5-11(6-8-13)18(24)22-16(19(25)26)9-12-10-17(23)21-15-4-2-1-3-14(12)15/h1-8,10,16H,9H2,(H,21,23)(H,22,24)(H,25,26) Y Key:ALLWOAVDORUJLA-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Studies have shown that rebamipide can fight the damaging effects of NSAIDs on the GIT mucosa,^[5] and more recently, the small intestine, but not for naproxen-induced gastric damage.^[6]

Availability

Rebamipide is used in a number of Asian countries including Japan (marketed as Mucosta), South Korea, China^[7] and India (where it is marketed under the trade name Rebagen). It is also approved in Russia under the brand name Rebagit.^[8]

Effects

Rebamipide increases gastric mucosal prostaglandin E2, protects gastric mucosa, thereby suppresses gastric mucosal damage and increases gastric mucus secretion and gastric mucosal blood flow, to improve hemodynamic impairment, suppress inflammation and repair the gastric mucosa. It is usually used to treat gastric ulcer and improve gastric mucosal lesion (erosion, bleeding, redness and edema) in acute gastritis and acute exacerbation period of chronic gastritis.