Red cell genotyping

Red cell genotyping^[1][2][3], also known as blood group genotyping,^[4][5][6][7] is a molecular technique used to identify genetic variants responsible for blood group antigens on the surface of red blood cells.

Unlike traditional serological testing, which relies on the presence of antibodies to detect antigens, genotyping analyzes DNA to determine an individual's blood group profile with high accuracy. This approach is particularly valuable in complex transfusion cases, such as in patients with multiple alloantibodies, hemoglobinopathies, or recent transfusions that can obscure serological results. Red cell genotyping enhances transfusion safety by enabling precise donor-recipient matching, reducing the risk of alloimmunization, and improving outcomes for patients requiring chronic transfusions, such as sickle cell disease and thalassemia.

See also

• Blood type
• Blood transfusion
• Blood compatibility testing
• ABO blood group system
• Rh factor testing