Relaxin receptor

The relaxin receptors are a subclass of four closely related G protein-coupled receptors (GPCR) that bind relaxin peptide hormones.^[1][2]

relaxin/insulin-like family peptide receptor 1
Identifiers
Symbol	RXFP1
Alt. symbols	LGR7
NCBI gene	59350
HGNC	19718
OMIM	606654
RefSeq	NM_021634
UniProt	Q9HBX9
Other data
Locus	Chr. 4 q31.3
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relaxin/insulin-like family peptide receptor 2
Identifiers
Symbol	RXFP2
Alt. symbols	LGR8, GREAT, GPR106, INSL3R
NCBI gene	122042
HGNC	17318
OMIM	606655
RefSeq	NM_130806
UniProt	Q8WXD0
Other data
Locus	Chr. 13 q12.3
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relaxin/insulin-like family peptide receptor 3
Identifiers
Symbol	RXFP3
Alt. symbols	RLN3R1, SALPR, GPCR135
NCBI gene	51289
HGNC	24883
OMIM	609445
RefSeq	NM_016568
UniProt	Q9NSD7
Other data
Locus	Chr. 5 p15.1-p14
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relaxin/insulin-like family peptide receptor 4
Identifiers
Symbol	RXFP4
Alt. symbols	GPR100, GPCR142, RLN3R2
NCBI gene	339403
HGNC	14666
OMIM	609043
RefSeq	NM_181885
UniProt	Q8TDU9
Other data
Locus	Chr. 1 q22
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Below is list of human relaxin receptors, their endogenous peptide hormones, and what downstream enzymes are activated or inhibited by the receptor.

receptor/gene	ligands	activates	inhibits
RXFP1	relaxin 1, relaxin 2, relaxin 3	adenylate cyclase, protein kinase A, protein kinase C, phosphatidylinositol 3-kinase, extracellular signal-regulated kinases (Erk1/2)
RXFP2	relaxin 1, relaxin 2, insulin-like 3	adenylate cyclase
RXFP3	relaxin 3	Erk1/2 signaling	adenylate cyclase
RXFP4	relaxin 3, insulin-like 3		adenylate cyclase

See also

• Relaxin family peptide hormones
• Insulin/IGF/Relaxin family
• Relaxin/insulin-like family peptide receptor 1