Reticular pigmented anomaly of the flexures

Reticular pigmented anomaly of the flexures (also known as dark dot disease and Dowling–Degos disease) is a fibrous anomaly of the flexures or bending parts of the axillae, neck and inframammary/sternal areas.^[2]: 856 It is an autosomal-dominant pigmentary disorder that may appear in adolescence or adulthood. This condition is due to mutations in structural/desmosomal proteins found within stratified squamous epithelium.^[3]

Reticular pigmented anomaly of the flexures
Other names	Kitamura reticulate acropigmentation[1]
Specialty	Dermatology

Dark dot disease is associated with KRT5.^[4]

See also

• List of cutaneous conditions
• List of cutaneous conditions caused by mutations in keratins
• Skin lesion