Rev-Erb

The Rev-Erb proteins are members of the nuclear receptor (NR) superfamily of intracellular transcription factors and key regulatory components of the circadian clock. There are two forms of the receptor, Rev-Erb alpha and Rev-Erb beta, which are each encoded by a separate gene (NR1D1 and NR1D2, respectively).^[1][2]  

Diagram showing how REV-ERB regulates circadian gene expression through the secondary loop of the circadian transcription/translation feedback loop (TTFL)

nuclear receptor subfamily 1, group D, member 1
Identifiers
Symbol	NR1D1
Alt. symbols	ear-1, hRev, Rev-ErbAalpha, THRA1
NCBI gene	9572
HGNC	7962
OMIM	602408
RefSeq	NM_021724
UniProt	P20393
Other data
Locus	Chr. 17 q11.2
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nuclear receptor subfamily 1, group D, member 2
Identifiers
Symbol	NR1D2
Alt. symbols	BD73, RVR, EAR-1r, HZF2, Hs.37288
NCBI gene	9975
HGNC	7963
OMIM	602304
RefSeq	XM_001130839
UniProt	Q14995
Other data
Locus	Chr. 3 p24.1
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These proteins act as key regulators of clock gene expression through transcriptional repression of Bmal1. Through their regulation of clock-controlled genes, the Rev-Erb proteins affect several physiological processes throughout the body, including metabolic, endocrine, and immune pathways.^[3][4][5]

In the NRNC classification scheme, Rev-Erb is nuclear receptor subfamily 1 group D (NR1D). The name "Rev-Erb" derived by truncation from "Rev-ERBA" (Rev-Erbα), which in turn was named because it was on the opposite strand of ERBA (THRA) oncogene. The paralogous Rev-Erbβ does not seem to have anything special on its reverse strand. Older sources may use "Rev-ERBA" as the family name.^[6]

The receptors are potential drug targets for non-alcoholic steatohepatitis.^[7]

See also

• Rev-Erbɑ
• Rev-Erbβ
• Nuclear Receptors
• Transcription Factors
• Circadian Clock