Rociverine

Rociverine is an antispasmodic drug used to treat urinary, gastrointestinal and biliary spasms.^[1] It is antimuscarinic drug.^[2]

Rociverine

Clinical data
ATC code	A03AA06 (WHO)
Identifiers
IUPAC name 1-(diethylamino)propan-2-yl (1S,2S)-2-cyclohexyl-2-hydroxycyclohexane-1-carboxylate
CAS Number	53716-44-2
PubChem CID	24892842
DrugBank	DB13581
ChemSpider	28534065
UNII	VI08KS44V0
KEGG	D07078
ChEBI	CHEBI:135440
ChEMBL	ChEMBL4755537
CompTox Dashboard (EPA)	DTXSID501023860
ECHA InfoCard	100.053.356
Chemical and physical data
Formula	C20H37NO3
Molar mass	339.520 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCN(CC)CC(C)OC(=O)[C@H]1CCCC[C@@]1(C2CCCCC2)O
InChI InChI=InChI=1S/C20H37NO3/c1-4-21(5-2)15-16(3)24-19(22)18-13-9-10-14-20(18,23)17-11-7-6-8-12-17/h16-18,23H,4-15H2,1-3H3/t16?,18-,20+/m1/s1 Key:XPYLKZZOBVLVHB-QDKIRNHSSA-N

Medical uses

In India, rociverine is used as part of the "Programmed Labour Protocol" to help reduce pain and shorten the duration of labor. However, an analysis of clinical trials provides little evidence supporting its effectiveness in reducing labor duration.^[3]

Pharmacology

The (1R,2R) stereoisomer showed 240-fold greater affinity for the muscarinic receptor, but the (1S,2S) compound showed the best selectivity. ^[4]