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Roman Zubarev

Russian chemist From Wikipedia, the free encyclopedia

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Roman A. Zubarev is a professor of medicinal proteomics in the Department of Medical Biochemistry and Biophysics at the Karolinska Institutet. His research focuses on the use of mass spectrometry in biology and medicine.

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Early life and education

Research interests

  • Electron-capture dissociation. In 1997, while in Fred McLafferty's lab at Cornell University, Zubarev discovered the phenomenon of electron-capture dissociation (ECD)[1] of polypeptides. He later developed ECD and other ion-electron reactions2 as analytical techniques in Odense (19982002) and Uppsala (20022008).
  • Isotopic resonance hypothesis. Discovered the phenomenon of isotopic resonance in Uppsala (2008),[2] formulated the isotopic resonance hypothesis and experimentally verified it in Stockholm (20092013).[3]
  • Isoaspartate theory of Alzheimer's disease. The role of isoaspartate in Alzheimer's disease has first been suggested as early as in 1991.[4] Over the next three decades the evidence gradually accumulated, being strongly supported by blood proteomics data.[5]
  • Origin of life studies. Zubarev showed that the organic matter produced abiotically in a Miller–Urey experiment can be assimilated by bacteria, and thus proved that early Earth has been a hospitable place for life.[6] For the first time in history of science, Zubarev obtained a living cell from dead matter.[7] In that landmark experiment, bacteria were separated into lipids, nucleic acids and proteins, and these ingredients were isolated and incubated separately and in a mixture. After incubation, the isolates were seeded on Petri dish. While isolated molecules showed no growth (negative control), lipid-containing mixtures gave bacterial colonies, proving that life can self-assemble from a mixture of right ingredients.
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Awards

  • Curt Brunnée Award, 2006
  • Biemann Medal, 2007[8]
  • Gold medal, Russian Mass Spectrometry Society, 2013

References

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