Rosolutamide

Rosolutamide
Clinical data
Other names	ASC-JM-17; ASC-JM17; JM17; ALZ-003; ALZ003
Identifiers
	IUPAC name (1E,6E)-4-(cyclobutylmethyl)-1,7-bis(3,4-dimethoxyphenyl)hepta-1,6-diene-3,5-dione;
CAS Number	1039760-91-2;
PubChem CID	25183127;
DrugBank	DB16931;
ChemSpider	64854816;
UNII	5VLL140BN9;
ChEMBL	ChEMBL5266600;
Chemical and physical data
Formula	C28H32O6
Molar mass	464.558 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COC1=C(C=C(C=C1)/C=C/C(=O)C(C(=O)/C=C/C2=CC(=C(C=C2)OC)OC)CC3CCC3)OC;
	InChI InChI=1S/C28H32O6/c1-31-25-14-10-20(17-27(25)33-3)8-12-23(29)22(16-19-6-5-7-19)24(30)13-9-21-11-15-26(32-2)28(18-21)34-4/h8-15,17-19,22H,5-7,16H2,1-4H3/b12-8+,13-9+; Key:PJOSHEDKRPRCAE-QHKWOANTSA-N;

Rosolutamide (INNTooltip International Nonproprietary Name; developmental code name ASC-JM17, JM17, ALZ-003) is an agonist of nuclear respiratory factor 1 (NRF1), a nonsteroidal antiandrogen, and an androgen receptor degrader related to curcumin.^[1]^[2]^[3]^[4]^[5] Other analogues like dimethylcurcumin (ASC-J9) are also known.^[2]^[6]

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See also