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SAM-IV riboswitch
RNA family From Wikipedia, the free encyclopedia
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SAM-IV riboswitches are a kind of riboswitch that specifically binds S-adenosylmethionine (SAM),[1] a cofactor used in many methylation reactions. Originally identified by bioinformatics,[2] SAM-IV riboswitches are largely confined to the Actinomycetales, an order of Bacteria. Conserved features of SAM-IV riboswitch and experiments imply that they probably share a similar SAM-binding site to another class of SAM-binding riboswitches called SAM-I riboswitches. However, the scaffolds of these two types of riboswitch appear to be quite distinct. The structural relationship between these riboswitch types has been studied.[3][4]
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