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SAS-1121
Compound which binds to the sigma-2 receptor, a cell-membrane protein From Wikipedia, the free encyclopedia
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SAS-1121 is an organic molecule which binds to a specific protein, the sigma-2 receptor, found in cell membranes. It is highly selective for this over the related sigma-1 receptor. The sigma-2 receptor is significant in cancer and some neurological illnesses.
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These two receptors are cell surface receptors: proteins in a cell membrane which pass a signal to the cell when some external molecule binds to them.
SAS-1121 is 280-fold selective for the sigma 2 receptor (Ki = 23.8 nM) [jargon] over the sigma 1 receptor (Ki = 6659.6 nM),[jargon][1] and served as a tool compound to help identify the sigma 2 receptor as transmembrane 97 (TMEM97).[2]
SAS-1121 is classed as a norbenzomorphan-piperazine.
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