SB-612,111

SB-612,111 is an opioid receptor ligand which is a potent and selective antagonist for the nociceptin receptor (ORL-1), several times more potent than the older drug J-113,397.^[1] It does not have analgesic effects in its own right, but prevents the development of hyperalgesia,^[2] and also shows antidepressant effects in animal studies.^[3]

SB-612,111

Clinical data
Other names	SB-612,111
Identifiers
IUPAC name (5S,7S)-7-{[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl}-1-methyl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ol
CAS Number	371980-98-2 N
PubChem CID	10047612
IUPHAR/BPS	1693
ChemSpider	8223175 N
ChEMBL	ChEMBL559569 N
CompTox Dashboard (EPA)	DTXSID301027159 DTXSID40610405, DTXSID301027159
Chemical and physical data
Formula	C24H29Cl2NO
Molar mass	418.40 g·mol−1
3D model (JSmol)	Interactive image Interactive image
SMILES CC1=CC=CC2=C1CC[C@@H](C[C@@H]2O)CN3CCC(CC3)C4=C(C=CC=C4Cl)Cl CC1=C2CC[C@@H](C[C@@H](C2=CC=C1)O)CN3CCC(CC3)C4=C(C=CC=C4Cl)Cl
InChI InChI=1S/C24H29Cl2NO/c1-16-4-2-5-20-19(16)9-8-17(14-23(20)28)15-27-12-10-18(11-13-27)24-21(25)6-3-7-22(24)26/h2-7,17-18,23,28H,8-15H2,1H3/t17-,23-/m0/s1 N Key:OHRDCQFCAWLDBP-SBUREZEXSA-N N
NY (what is this?)  (verify)

See also

• JTC-801
• J-113,397
• LY-2940094