Mammaglobin-A

Mammaglobin-A also known as secretoglobin family 2A member 2 is a protein that in humans is encoded by the SCGB2A2 gene.^[5][6][7]

SCGB2A2
Identifiers
Aliases	SCGB2A2, MGB1, UGB2, secretoglobin family 2A member 2, PSBP1
External IDs	OMIM: 605562; HomoloGene: 82995; GeneCards: SCGB2A2; OMA:SCGB2A2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q12.3 Start 62,270,158 bp[1] End 62,273,160 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 A Start 9,847,562 bp[2] End 9,852,808 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of thigh skin of arm skin of hip epithelium of lactiferous gland lactiferous duct testicle olfactory zone of nasal mucosa skin of abdomen minor salivary glands gonad Top expressed in embryo embryo genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding molecular function Cellular component cellular component extracellular region extracellular space Biological process biological process androgen receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4250 102639117 Ensembl ENSG00000110484 ENSMUSG00000096872 UniProt Q13296 J3KMP9 RefSeq (mRNA) NM_002411 XM_006527538 RefSeq (protein) NP_002402 NP_001365339 Location (UCSC) Chr 11: 62.27 – 62.27 Mb Chr 19: 9.85 – 9.85 Mb PubMed search [3] [4]
Wikidata
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Function

SCGB2A2 is a member of the superfamily of secretoglobins, a group of small dimeric secreted and sometimes glycosylated proteins. Expressed mainly in mucosa, secretoglobins seem to be involved in cell signalling, immune response, and chemotaxis, and may also serve as transporters for steroid hormones in humans.^[8]

Clinical significance

SCGB2A2 expression is highly specific of mammary tissue, and is increasingly used for identification and detection of disseminated breast cancer cells.^[9]