Syndecan-2

Syndecan-2 is a protein that in humans is encoded by the SDC2 gene.^[5]

SDC2
Identifiers
Aliases	SDC2, CD362, HSPG, HSPG1, SYND2, syndecan 2
External IDs	OMIM: 142460; MGI: 1349165; HomoloGene: 2253; GeneCards: SDC2; OMA:SDC2 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q22.1 Start 96,493,813 bp[1] End 96,611,790 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 B3.1|15 13.74 cM Start 32,920,869 bp[2] End 33,035,081 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia Achilles tendon synovial joint retinal pigment epithelium left lobe of thyroid gland right coronary artery right lobe of thyroid gland popliteal artery tibial arteries Descending thoracic aorta Top expressed in epithelium of lens vestibular sensory epithelium calvaria body of femur ciliary body iris ankle retinal pigment epithelium left lobe of liver pituitary gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function PDZ domain binding protein binding identical protein binding Cellular component integral component of membrane membrane plasma membrane lysosomal lumen Golgi lumen endoplasmic reticulum lumen cell surface extracellular matrix collagen-containing extracellular matrix Biological process glycosaminoglycan metabolic process cell differentiation ephrin receptor signaling pathway nervous system development retinoid metabolic process regulation of dendrite morphogenesis bioluminescence glycosaminoglycan catabolic process glycosaminoglycan biosynthetic process leukocyte migration post-translational protein modification cell migration dendrite morphogenesis biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6383 15529 Ensembl ENSG00000169439 ENSMUSG00000022261 UniProt P34741 P43407 RefSeq (mRNA) NM_002998 NM_008304 RefSeq (protein) NP_002989 NP_032330 Location (UCSC) Chr 8: 96.49 – 96.61 Mb Chr 15: 32.92 – 33.04 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types.^[6]

Interactions

SDC2 has been shown to interact with:

• CASK,^[7][8]
• Laminin, alpha 3,^[9] and
• EZR^[10]