SDZ SER-082

SER-082, or SDZ SER-082, is a selective serotonin 5-HT_2B and 5-HT_2C receptor antagonist or weak partial agonist with an ergoline-like structure which is used in scientific research.^[1][2][3] It shows similar affinity for the serotonin 5-HT_2B and 5-HT_2C receptors and has ~40-fold higher affinity for the serotonin 5-HT_2C receptor over the closely related serotonin 5-HT_2A receptor.^[1][3]

SDZ SER-082

Clinical data
Other names	SDZ SER-082; SDZ SER082
Drug class	Selective serotonin 5-HT2B and 5-HT2C receptor antagonist or weak partial agonist
Identifiers
IUPAC name (2R,7S)-4-methyl-4,9-diazatetracyclo[7.6.1.02,7.012,16]hexadeca-1(15),12(16),13-triene
CAS Number	141474-54-6 Y
PubChem CID	9859407
IUPHAR/BPS	195
ChemSpider	8035107 Y
UNII	M7FHF24Q22
ChEMBL	ChEMBL316069
CompTox Dashboard (EPA)	DTXSID001028477
Chemical and physical data
Formula	C15H20N2
Molar mass	228.339 g·mol−1
3D model (JSmol)	Interactive image
SMILES CN1CC[C@@H]2CN3CCC4=C3C(=CC=C4)[C@@H]2C1
InChI InChI=1S/C15H20N2/c1-16-7-5-12-9-17-8-6-11-3-2-4-13(15(11)17)14(12)10-16/h2-4,12,14H,5-10H2,1H3/t12-,14-/m1/s1 N Key:YASBOGFWAMXINH-TZMCWYRMSA-N N
(verify)

It has been used in animal studies into the behavioural effects of the different 5-HT₂ subtypes,^[4][5][6] and how they influence the effects of other drugs such as cocaine.^[7][8][9] The drug has been found to have no effect on anxiety in multiple paradigms in rodents.^[10] In contrast to other serotonin 5-HT_2C receptor antagonists, SER-082 does not produce hyperlocomotion in rodents, and instead can produce hypolocomotion at high doses that is independent of the serotonin 5-HT_2C receptor.^[11]

It fails to block the effects of serotonergic psychedelics in multiple behavioral paradigms, in contrast to serotonin 5-HT_2A receptor antagonists.^[12][13][14] However, the hypolocomotion induced by high doses of the phenethylamine psychedelic DOI can be attenuated by SER-082.^[15] Conversely, the drug was ineffective against the hypolocomotion induced by the tryptamine psychedelic 5-MeO-DMT, whereas the serotonin 5-HT_1A receptor antagonist WAY-100635 was effective.^[16]

See also

• Lysergine