Semenogelin I

Semenogelin-1 is a protein that in humans is encoded by the SEMG1 gene.^[3][4][5] The protein encoded by this gene is the predominant protein in semen. The encoded secreted protein is involved in the formation of a gel matrix that encases ejaculated spermatozoa. The prostate-specific antigen (PSA) protease processes this protein into smaller peptides, with each possibly having a separate function. The proteolysis process breaks down the gel matrix and allows the spermatozoa to move more freely. Two transcript variants encoding different isoforms have been found for this gene.^[5]

SEMG1
Identifiers
Aliases	SEMG1, CT103, SEMG, SGI, dJ172H20.2, Semenogelin I, semenogelin 1
External IDs	OMIM: 182140; HomoloGene: 130511; GeneCards: SEMG1; OMA:SEMG1 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.12 Start 45,207,033 bp[1] End 45,209,768 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in seminal vesicula sperm prostate gallbladder epithelium of colon thymus synovial joint blood islet of Langerhans mucosa of nose n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding zinc ion binding Cellular component extracellular region extracellular exosome nucleus extracellular space protein-containing complex Biological process negative regulation of calcium ion import insemination antibacterial humoral response positive regulation of serine-type endopeptidase activity protein heterooligomerization negative regulation of flagellated sperm motility antimicrobial humoral response coagulation sperm capacitation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6406 n/a Ensembl ENSG00000124233 n/a UniProt P04279 n/a RefSeq (mRNA) NM_198139 NM_003007 n/a RefSeq (protein) NP_002998 n/a Location (UCSC) Chr 20: 45.21 – 45.21 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

See also

• Semenogelin