SEPTIN1

Septin-1 is a protein that in humans is encoded by the SEPTIN1 gene.^[5][6] It was renamed from SEPT1 to avoid problems where Microsoft Excel would auto-correct the gene name to the date September 1.^[7]

SEPTIN1
Identifiers
Aliases	SEPTIN1, DIFF6, LARP, PNUTL3, SEP1, septin 1, SEPT1
External IDs	OMIM: 612897; MGI: 1858916; HomoloGene: 23009; GeneCards: SEPTIN1; OMA:SEPTIN1 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p11.2 Start 30,378,135 bp[1] End 30,395,991 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F3 Start 126,813,619 bp[2] End 126,832,302 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte appendix spleen lymph node thymus blood bone marrow cell mucosa of transverse colon rectum sural nerve Top expressed in granulocyte thymus ventricular zone blood blastocyst morula spleen neural layer of retina lymph node genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding protein binding identical protein binding GTPase activity molecular adaptor activity Cellular component cytoplasm cytoskeleton microtubule organizing center midbody septin ring synaptic vesicle microtubule cytoskeleton septin complex septin filament array Biological process cell division cell cycle mitotic cytokinesis septin ring assembly regulation of exocytosis cilium assembly cytoskeleton-dependent cytokinesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1731 54204 Ensembl ENSG00000180096 ENSMUSG00000000486 UniProt Q8WYJ6 P42209 RefSeq (mRNA) NM_052838 NM_001365977 NM_017461 RefSeq (protein) NP_443070 NP_001352906 NP_059489 Location (UCSC) Chr 16: 30.38 – 30.4 Mb Chr 7: 126.81 – 126.83 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. This gene encodes a protein associated with the tau-based paired helical filament core, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease.^[6]